Tag Archives: RNA virus

Tiny particles with big consequences: The number of viruses it takes to start an infection

 

Hepatitis virions, of an unknown strain of the...
Hepatitis virions (Photo credit: Microbe World)

My last post was written to introduce the concept of quasispecies in an RNA virus population.

This article will further expand on the topic and show how the quasispecies concept was used with powerful genetic sequencing technology to figure out a specific question: How many hepatitis C virus particles does it take to start an infection in humans? Continue reading Tiny particles with big consequences: The number of viruses it takes to start an infection

Advertisements

The Concept of Quasispecies

RNA Polymerase
RNA Polymerase (Photo credit: ynse)

Today’s topic is directly related to my own research with RNA viruses and is what I consider a very interesting topic: quasispecies.

Many of us are familiar with the concept of a species at the macro (visible) scale. Dogs are dogs; pigs are pigs, and so on. Each is a distinct species based on the fact that they can only reproduce and generate fertile offspring with other members of the same species. Over the course of many generations mutations may arise in these populations which lead to different genotypes in the species. Left long enough, these two subpopulations may keep mutating to the point where they can no longer interbreed and become their own genetically distinct species. However, when you get down to the viral scale species becomes a much more difficult concept. Viruses don’t have sex in the traditional sense, so how can they be a species?

Continue reading The Concept of Quasispecies